Today I want to discuss an interesting clinical study, Aloctin A, An Active Substance Of Aloe Arborescens Miller As An Immunomodulator, done by Ken’ichi Imanishi. In this study, Aloctin A was implanted into mice against two different tumor cells.
Aloctin A is an active ingredient that is found in the leaves of Aloe Arborescens. Aloctin A is a highly purified glycoprotein. Ken’ichi Imanishi described in the study that Aloctin A shows a number of biological activities. Some of these activities are “mitogenic activity for T lymphocytes, binding reactivity for human a2-macroglobulin and activation of component 3 of complement system via the alternative pathway”.
In the clinical study, two variations of the experiment were done. Conclusions were made from an experiment from Aloctin A against methylcholanthrene-induced murine fibrosarcoma (Meth A)2, and also between Aloctin A against lymphocytic leukemia (P388). In the first variation of the experiment, one million Meth A cells were implanted into mice. 24 hours after Meth A was implanted, the mice were administered Aloctin A once daily for five days. Results showed that Aloctin A did not directly have an effect on Meth A. In the second variation of the experiment, P388 was implanted into mice. Aloctin A was administered once daily on the first and fifth days after P388 implantation. From this experiment, it was concluded that “Aloctin A is a promising candidate as an immunomodulator”.
I hope that you found this week’s blog post interesting! Stay tuned for next Tuesday!